Nitric oxide, Autoimmune and chronic disease
Nitric oxide for autoimmune and chronic disorders
When it comes to autoimmune disease and other chronic health conditions, taming inflammation is the name of the game. This can be difficult because the body creates vicious cycles where inflammation keeps feeding more inflammation. This makes halting the progression of autoimmune disease and chronic health issues difficult…but not impossible.
However, we now know about nutritional ingredients that can boost anti-inflammatory efforts. These ingredients act on two inflammatory immune messengers called “nitrous oxide” and Interluekin 17 or “IL-17.”
IL-17 is a pro-inflammatory immune cell that damages body tissue, such as the thyroid gland in autoimmune Hashimoto’s, the joints in rheumatoid arthritis, or the nerve sheaths in multiple sclerosis.
IL-17 isn’t completely bad—it’s necessary to fight infection. But when the immune system becomes hyper zealous, IL-17 goes out of control and attacks the body it’s designed to protect.
IL-17 destroys tissue by activating a “inducible nitric oxide,” one of three forms of nitric oxide, a gas, involved in various processes in the body. Two other two forms of nitric oxide are beneficial and actually fight inflammation: endothelial nitric oxide and neuronal nitric oxide.
However, inducible nitric oxide is pro-inflammatory and damages body tissue under the orders of IL-17.
Therefore, one way we can stop the vicious cycle of inflammation is to dampen IL-17 and inducible nitric oxide. Luckily, there are nutritional compounds that help the body do this.
But first — perhaps you’ve heard of arginine to boost nitric oxide. Although arginine boosts the anti-inflammatory endothelial and neuronal nitric oxides, it also boosts inducible nitric oxide. So if you are fighting chronic inflammation, taking arginine may work against you.
Arginine is also touted as being good for boosting growth hormone. But, this can have down sides. Check out my previous post on Arginine and cold sores.
It’s safer instead to take nutritional compounds that studies show support endothelial nitric oxide (one of the anti-inflammatory nitric oxides). These include:
Xanthinol niacinate - a form of niacin
These compounds work synergistically taken together in an emulsified liquid form (very hard to find and generally only found in functional medicine offices). But not everybody can or should take a liquid form.
Not only does boosting endothelial nitric oxide tame inflammation, it also helps repair and regenerate body tissue, promote blood flow, dissolve plaques, and dilate blood vessels. Start with small doses to gauge effects and tolerance.
These compounds also support neuronal nitric oxide (the other anti-inflammatory nitric oxide) and thus the health of your brain and nervous system.
Exercise is another excellent way to boost beneficial nitric oxides. In fact, take these endothelial nitric oxide boosting compounds before getting your heart rate to maximum capacity for a few minutes first thing in the morning. This will optimize anti-inflammatory effects and support brain health. Nitric oxide is helpful for those of use that like to lift weights and enjoy that “pumped feeling during and after the workout.
Also, nitric oxide is what is stimulated with certain medications such viagra and heart medications for angina. Taking these supplements can also help men with issues in the bedroom. “Make you strong like oak”
You don’t have to exercise long — just a few minutes of raising your heart rate as high as you can has profound anti-inflammatory and brain supporting effects. Just be sure not to over train as that produces more inflammation. Also, how you get your heart rate up depends on your fitness level and abilities, so keep it safe and doable.
Other tools to tame inflammation include therapeutic doses of vitamin D3, omega 3 fatty acids, absorbable forms of glutathione, and therapeutic doses of emulsified resveratrol and curcumin. These compounds have been shown to dampen the the inflammatory vicious cycles associated with autoimmune and chronic disorders.
Of course, lifestyle and diet changes are vital too. This includes eliminating pro-inflammatory foods with the autoimmune diet and designing an inflammation-quenching lifestyle.
For help taming your chronic inflammation and autoimmune disorder, ask my office for advice.
Until Next time,
I’m Dr. Craig Mortensen
Be healthy, Be happy.